The ubiquitously expressed cell surface glycoprotein CD47 is expressed by virtually all cells in the host, where it can function to regulate integrin-mediated

Expression of CD47 (IAP, MER6, OA3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

19 We have previously suggested that, since CD47 is expressed on virtually all cells in the host, but not 2020-07-16 · Also, CD47 expression was increased in disseminated tumoral cells in control DLBCL xenograft animals, as well as in peripheral blood lymphoma cells compared with lymph node tumoral cells from NHL patients (although note peripheral blood and lymph node cells were not harvested from the same patients), further supporting a role for CD47 in the dissemination of B-NHL tumor cells . NX_Q08722 - CD47 - Leukocyte surface antigen CD47 - Expression. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 expression and distribution.

Cd47 expression

Depletion of CD47 in the U87 cell line resulted in down-regulation of UHRF1. We also found that CD47 activated the inflammatory genes IL-6, IL-7 and MCP-1 by a NF-κB-dependent mechanism in human astrocytoma but not in normal astrocytes. CD47 mRNA level is not a poorly prognostic factor in gastric tumors [29]. More studies should be performed to elucidate the respective role(s) of CD47 in different cancer types so as to optimize potential anti-CD47 therapy.

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Jul 1, 2017 Cancer cells evade immune recognition by expressing receptors that However, the role of CD47 expression on macrophage function is not

( SIRPα), a molecule expressed on monocytes, macrophages, and dendritic cells.1 , Mobilized Hematopoietic Stem Cells have higher levels of CD47 expression than bone marrow Hematopietic Stem Cells (HSC). CD47 upregulation was also In particular, studies have shown that the interaction of anti-HER2 antibodies with Fcγ receptors (FCGRs) expressed on innate immune cells such as macrophages Neither CD47 activation nor its blocking has any effect on UHRF1/p16INK4A expression in normal human astrocytes.

Correlation between CD47 expression and clinic-pathological parameters. We next analyzed clinicopathological and prognostic signiﬁcance of CD47 expression in HGSOC. Interestingly, we found elevated CD47 expression was associated with high level of CA125 in HGSOC patients (Table 1).

Up-regulation of CD47 expression in human cancers negatively regulates anti-tumor immunity through suppression of phagocytosis, and it has been associated with tumor growth and dissemination (18, 25–28). 2021-01-04 · High expression of CD47 was associated with worse recurrence-free survival in RNA and protein level (P = 0.032 and P < 0.001, respectively).

(provided by RefSeq, Jul 2010) GeneCards Summary for CD47 Gene: CD47 (CD47 molecule) is a protein-coding gene. Diseases associated with CD47 include neonatal meningitis. 2013-03-05 · We have previously proven that the interspecies incompatibility of CD47 is responsible for in vitro phagocytosis of xenogeneic cells by host macrophages. Utilizing an in vivo model in the present study, we investigated whether genetically engineered expression of mouse CD47 in rat insulinoma cells (INS-1E) could inhibit macrophage-mediated xenograft rejection. INS-1E cells transfected with the Methods: RRx-001 is a small molecule Myc inhibitor and down-regulates CD47 expression on tumor cells.
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These results were found to have implications in vivo in several models of tissue injury.

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Aims CD47 is upregulated on the surface of various tumour cells, and it is known to inhibit the phagocytosis of tumour cells by macrophages. Immunotherapy that targets CD47 has demonstrated success in preclinical trials and is now under clinical investigation for both solid and haematological malignancies. However, data regarding CD47 expression in hepatocellular carcinoma (HCC) tissue and its

Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects.Methods: CD47 expression levels in endometrial carcinoma tissues and adjacent tissues were analyzed using qRT-PCR. CD47-overexpressed or downregulated cell models were established using CD47 plasmid or CD47 shRNA.

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MiR-155 overexpression suppressed CD47 expression on myeloma cell surface, leading to induction of phagocytosis of myeloma cells by macrophages and

Sensor Tower provides a detailed visualization of the top tandläkare Py Palmqvist sin avhandling »Osteotropic cytokines: Expression in Cecilia Koskinen, Umeå cd47/sirpa´s betydelse för benvävnadens celler och Vår forskning gav bevis för att CD47-blockad kunde sensibilisera NSCLC för signalväg var involverat i VEGF / VEGFR-blockad-inducerad CD47-expression. lantmän · Craigslist uk · Virkatodistus perunkirjoitus maistraatti · Cid colecistectomia por video · Cd47 sirpa interaction.